Hi there, 3 months ago we adopted a yellow lab puppy (or what at the time we assumed was a lab mix) from our local shelter. The vet estimates that he was born between October-November 2019 which now makes him around 8 months old. In order to gain a bit more perspective on his health and genetics we had him tested with Embark's full panel. Even though he appears to be built a bit smaller than a typical lab and has facial characteristics that made both us and the vet believe that he may be part shar pei, the test indicated that he is 100% labrador, something which I was dreading as the shelter informed us that the area he was found in has a few infamously bad breeders. Furthermore, the test confirmed that his COI is 25% which i assume means that his parents were siblings. Additionally, the test confirmed that he has both genes associated with Hereditary Nasal Parakeratosis which in his case is already evident as the edges of his nose are a bit dry and scaly (not worried about this as its manageable). Finally (and worst of all), the test indicated that he has 2 copies of a risk variant associated with Progressive Retinal Atrophy, which from what I understand means that he will, unfortunately, go blind on average by the age of 5. In the past 3 months he developed lameness in his front right leg and after an X-ray and subsequent CT scan he was diagnosed with osteochondrosis (OCD) on both shoulders (the right one is more severe and thus symptomatic) and his hind legs seem to have a degree of hip dysplasia which the vet recommends we monitor until he's a bit older. I wrote out the above for two reasons: a) to ask whether anyone has any input on the above or has similar experiences with such a high degree of inbreeding or with PRA b) to make my puppy's story public and to serve another warning against the dangers of reckless breeding.