Hi everybody, our Sam is a black lab and is 9 years old. A few weeks ago he developed granuloma between the toes on both paws. The therapy was antibiotics, cortisone and apoquel.The granuloma started to shrink but only to come back the next day same size. We tried aknefug and an essential oil. Nothing. For a week he is now on cyclavance and he takes it well, no side effects yet. It says it takes about 4 weeks to show some effects and I wonder if somebody has some experience with that medication. Thanks very much for advice. Klaus and SAM